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AWWA ACE63005
- The Emergence and Divergence of Antimicrobial Resistance in Pseudomonas aeruginosa Biofilms
- Conference Proceeding by American Water Works Association, 06/01/2006
- Publisher: AWWA
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To effectively prevent biofilms, which are prevalent in chlorinated drinking waterdistribution systems, the effect of biofilm age on antimicrobial resistance must beinvestigated. In this study, young and mature biofilms of Pseudomonas aeruginosa, amodel biofilm organism, were grown and exposed to antimicrobial agents in severaldifferent treatments. Results showed that the increased antimicrobial resistance in biofilmcells compared to planktonic cells arises early in biofilm development. The short-termtolerance of resuspended mature biofilm cells to antimicrobial agents peaked at a biofilmage of 14 days, and subsequently declined, whereas the antimicrobial resistance ofresuspended mature biofilm cells continuously exposed to antimicrobial agents increasedwith biofilm age. Furthermore, individual members in mature biofilm communitiesexhibited variation in antimicrobial resistance. Includes 3 references.
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